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Medchemexpress LLC Selonsertib | 1448428-04-3 | 99.1% | 445.49 | 200 MG
Supplier: Medchemexpress LLC HY18938200MG
Selonsertib (GS-4997) is an orally bioavailable, selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3. It has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis. It is a highly selective and potent once-daily oral ASK1 inhibitor that competes with ATP in the ASK1 catalytic kinase domain.
- Orally bioavailable.
- Selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor.
- pIC50 of 8.3 for ASK1.
- Competes with ATP in the ASK1 catalytic kinase domain.
- Highly selective and potent once-daily oral ASK1 inhibitor.
- Evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis.
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