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Medchemexpress LLC Selumetinib | 606143-52-6 | 99.6% | C17H15BrClF4O3 | 200 MG
SDP

Supplier:  Medchemexpress LLC HY50706200MG

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Selumetinib is a selective, non-ATP-competitive oral MEK1/2 inhibitor with an IC50 of 14 nM for MEK1. It inhibits ERK1/2 phosphorylation and can penetrate the blood-brain barrier. This compound causes a time- and dose-dependent reduction in DNA synthesis and cell viability, inducing growth arrest and apoptosis associated with ERK inactivation.

  • Selective, non-ATP-competitive oral MEK1/2 inhibitor
  • Inhibits ERK1/2 phosphorylation
  • Penetrates the blood-brain barrier
  • Induces growth arrest and apoptosis
  • Shows anti-proliferative effects

Catalog No. 50-003-58183


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