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Apexbio Technology LLC Sennoside A 81-27-6 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC N16785.1
Sennoside A (CAS 81-27-6) is a small-molecule inhibitor targeting HIV-1 replication It is designed to inhibit HIV-1 reverse transcriptase (RT)-related DNA polymerase (RDDP) activity and ribonuclease H thereby suppressing viral replication pathways Sennoside A exerts its biological activity primarily through competitive inhibition of both DNA polymerase and ribonuclease H activities of HIV-1 RT In in vitro studies Sennoside A demonstrates inhibitory activity with IC50 values of 3 8 M for HIV-1 replication 1 9 M for DNA polymerase activity and 5 3 M for ribonuclease H activity Based on these pharmacological properties Sennoside A holds research potential in antiviral studies targeting HIV-1
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