AnaSpec SENSOLYTE 520 MOUSE RENIN ASS

Supplier:  AnaSpec AS72161

SensoLyte 520 Mouse Renin Assay Kit Fluorimetric, (1 kit) Renin, a highly specific aspartyl protease, cleaves angiotensinogen, to yield angiotensin I. Angiotensin I is further converted into angiotensin II by ACE (Angiotensin Converting Enzyme). Angiotensin II constricts blood vessels leading to increased blood pressure. Discovery of new renin inhibitors for treatment of hypertension is a promising area of research. The SensoLyte 520 Mouse Renin Assay Kit provides a convenient assay for high throughput screening of renin inhibitors and for continuous assay of mouse renin activity using a 5-FAM/QXL520 FRET peptide. In the FRET peptide the fluorescence of 5-FAM is quenched by QXL520. Upon cleavage into two separate fragments by renin, the fluorescence of 5-FAM is recovered, and can be monitored at excitation/emission = 490/520 nm.

Catalog No. NC0345991