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Medchemexpress LLC SETD2-IN-1 (TFA) | 2411759-92-5 | 97.2% | 514.51 | 100 MG
Supplier: Medchemexpress LLC HY136328100MG
EZM0414 TFA is the TFA salt form of EZM0414. It is a potent, selective, and orally active inhibitor of SETD2, with an IC50 of 18 nM in a biochemical assay and 34 nM in a cellular assay. This product is intended for research related to relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma.
- Potent, selective, and orally active inhibitor of SETD2.
- Inhibits proliferation of multiple myeloma and diffuse large B-cell lymphoma cell lines.
- Demonstrated robust tumor growth regressions in xenograft models.
- Correlated with reductions in intratumoral H3K36me3 levels.
- Well-tolerated in animal models.
- Exhibits high oral bioavailability in rats and mice.
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