Medchemexpress LLC Sevabertinib | 2521285-05-0 | 99.9% | 484.93 | 25 MG

Supplier:  Medchemexpress LLC 25MGHY164718

Sevabertinib (BAY 2927088) is an orally active and reversible dual EGFR-HER2 inhibitor with IC50 values of <0.5 nM for wild-type HER2, HER2 A775insYVMA, wild-type EGFR, and EGFR D770_N771insSVD. It demonstrates anticancer activity against lung cancer.

• Orally active and reversible dual EGFR-HER2 inhibitor.
• Potent inhibition of multiple HER2 and EGFR forms (IC50 <0.5 nM).
• Shows anticancer activity against lung cancer.
• Inhibits proliferation of isogenic Ba/F3 cells with HER2 exon 20 insertions or resistance mutations.
• Potently inhibits proliferation of NCI-H1781 and NCI-H2170 lung cancer cell lines.
• Demonstrates tumor growth inhibition in PDX mouse models of NSCLC.
• Shows antitumor efficacy in NCI-H1781 xenograft mouse model.

Catalog No. 50-003-94787