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Medchemexpress LLC SEW2871 | 256414-75-2 | 99.9% | 440.36 | 5 MG
Supplier: Medchemexpress LLC HYW0089475MG
SEW2871 is an orally active, potent, and highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist with an EC50 of 13.8 nM. It activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. This compound reduces lymphocyte numbers in the blood and is used for research into diabetes, Alzheimer's disease, liver fibrosis, and inflammatory responses.
- Highly selective S1P1 agonist (EC50 of 13.8 nM).
- Activates ERK, Akt, and Rac signaling pathways.
- Induces S1P1 internalization and recycling.
- Reduces lymphocyte numbers.
- Orally active.
- Ameliorates experimental colitis (in vivo).
- Inhibits Alzheimer's disease symptoms (in vivo).
- Attenuates acute inflammatory lung injury (in vivo).
- Protects kidneys against ischaemia-reperfusion injury (in vivo).
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