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Apexbio Technology LLC SF1670 345630-40-2 50mg
Supplier: Apexbio Technology LLC B478750
SF1670 (CAS 345630-40-2) is a selective inhibitor targeting the phosphatase PTEN (phosphatase and tensin homolog deleted on chromosome 10) an enzyme that converts phosphatidylinositol (3 4 5)-trisphosphate (PIP3) into phosphatidylinositol 4 5-bisphosphate (PIP2) Inhibition by SF1670 elevates PIP3 signaling and Akt phosphorylation in neutrophils enhancing their chemotactic responsiveness and reactive oxygen species (ROS) production in response to fMLP stimulation SF1670 has demonstrated utility in improving neutrophil-mediated bacterial clearance and mitigating inflammation-associated lung injury in murine models of neutropenia-related bacterial pneumonia
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