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Apexbio Technology LLC SGC 0946 1561178-17-3 5mg
Supplier: Apexbio Technology LLC A41675
SGC 0946 (CAS 1561178-17-3) is a small molecule inhibitor targeting DOT1L a histone methyltransferase responsible for methylation of lysine 79 on histone H3 (H3K79) By selectively inhibiting DOT1L catalytic activity SGC 0946 disrupts H3K79 methylation showing potent inhibitory potency (IC50 0 3 nM) In cellular assays SGC 0946 reduces H3K79 methylation in MCF10A and A431 cell lines with IC50 values of 8 8 nM and 2 65 nM respectively Structurally related to EPZ004777 but as a brominated analog SGC 0946 has improved cellular permeability and prolonged target residence time facilitating research in epigenetic regulation
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