Apexbio Technology LLC SH-4-54 1456632-40-8 25mg

Supplier:  Apexbio Technology LLC B478925

SH-4-54 (CAS 1456632-40-8) is a small-molecule inhibitor targeting signal transducer and activator of transcription 3 (STAT3) with reported dissociation constants (K sub D /sub ) of approximately 300 nM for STAT3 and 464 nM for STAT5 By binding the STAT3 SH2 domain SH-4-54 disrupts interactions with phosphotyrosine peptides selectively inhibiting phosphorylation at Tyr705 (pSTAT3 Y705) without affecting Ser727 phosphorylation In vitro studies indicate lowered expression of downstream proteins cyclin D1 and Bcl-xL In mouse xenograft models using BT73 glioblastoma cells SH-4-54 treatment decreased tumor cell viability reduced STAT3 phosphorylation and promoted apoptosis highlighting its potential for glioblastoma and cancer stem cell research

Catalog No. 50-000-63634