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Medchemexpress LLC SHIN1 (RZ-2994) | 2146095-85-2 | 98.6% | 400.47 | 100 MG
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Supplier:  Medchemexpress LLC HY112066A100MG

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SHIN1 (RZ-2994) is a human serine hydroxymethyltransferase 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay. It is for research use only and not sold to patients.

  • Inhibits human SHMT1/2 with IC50s of 5 nM (SHMT1) and 13 nM (SHMT2) in an in vitro assay.
  • Inhibits the growth of SHMT2 deletion HCT-116 cells with an IC50 of 10 nM.
  • Particularly active against B-cell malignancies.
  • Blocks cell growth through a progressive depletion of purines, leading to loss of nucleotide triphosphates.

Catalog No. 50-004-37346


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