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Medchemexpress LLC SHP389 100mg | 2235394-90-6 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY114453100MG

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SHP389 is an allosteric inhibitor of the SHP2 protein tyrosine phosphatase. It inhibits SHP2 and downstream p-ERK with an IC50 of 36 nM, modulates MAPK signaling in vivo, and exhibits antiproliferative activity in cell-based assays.

  • Allosteric SHP2 inhibitor (IC50 36 nM for SHP2 and p-ERK).
  • Modulates MAPK signaling in vivo.
  • Shows antiproliferative activity in Detroit 562 cells (IC50 4.13 μM at 24 h).
  • High purity (98.03%).
  • Solid, white to off-white appearance; soluble in DMSO (100 mg/mL).

Catalog No. 50-002-28589


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