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Medchemexpress LLC SI-109 | 2429877-30-3 | 99.0% | 10 MG
Supplier: Medchemexpress LLC HY12960310MG
SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) that exhibits antitumor activity. It effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM). This compound has been utilized, along with an analog of the CRBN ligand lenalidomide, to design the PROTAC STAT3 degrader SD-36.
- Potent STAT3 SH2 domain inhibitor
- Exhibits antitumor activity
- Inhibits transcriptional activity of STAT3
- Used in the design of PROTAC STAT3 degrader SD-36
- Exerts moderate growth inhibitory activity in MOLM-16 cells
- Solid, white to off-white appearance
- Shipped with dry ice
- Store at -80°C, under nitrogen
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