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Medchemexpress LLC SI-W052 | 2572552-60-2 | 98.0% | 434.89 | 5 MG
Supplier: Medchemexpress LLC HY1740665MG
SI-W052 is an orally active, brain-penetrant and selective small-molecule inhibitor targeting mTOR and TEX264. It activates autophagy by inhibiting mTOR phosphorylation and enhances TEX264 expression to promote ER turnover, thereby suppressing LPS-induced release of inflammatory factors (TNF-α, IL-6). It shows promise for research related to Alzheimer's disease (AD)-associated neuroinflammation.
- Orally active and brain-penetrant
- Selective small-molecule inhibitor targeting mTOR and TEX264
- Activates autophagy by inhibiting mTOR phosphorylation
- Enhances TEX264 expression to promote ER turnover
- Suppresses LPS-induced release of inflammatory factors (TNF-α, IL-6)
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