Medchemexpress LLC Si-W052 | 2572552-60-2 | 98.0% | 434.89 g·mol⁻¹ | C20H19ClN2O5S | 10 MG

Supplier:  Medchemexpress LLC HY17406610MG

SI-W052 is an orally active, brain-penetrant small-molecule inhibitor that selectively targets mTOR and TEX264 to activate autophagy and promote endoplasmic reticulum turnover. It inhibits mTOR phosphorylation and reduces LPS-induced release of inflammatory cytokines, supporting research into neuroinflammation and Alzheimer's-associated pathways.

• Orally active and brain-penetrant.
• Selective inhibitor of mTOR and TEX264.
• Activates autophagy via inhibition of mTOR phosphorylation.
• Enhances TEX264 expression to promote endoplasmic reticulum turnover.
• Reduces LPS-induced release of inflammatory cytokines such as TNF-α and IL-6.
• Supplied as a high-purity solid with defined storage conditions for stability.

Catalog No. 50-002-99176