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Medchemexpress LLC SIAIS164018 hydrochloride | 2353492-68-7 | 98.1% | 919.79 | 5 MG
Supplier: Medchemexpress LLC HY147219A5MG
SIAIS164018 hydrochloride is a PROTAC-based degrader targeting ALK and EGFR. It exhibits potent inhibition with IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R, effectively inhibiting cancer cell migration and invasion. This compound also induces G1 cell cycle arrest and promotes apoptosis, demonstrating superior properties.
- Functions as a PROTAC-based degrader for ALK and EGFR
- Exhibits potent inhibition with IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R
- Strongly inhibits cancer cell migration and invasion
- Causes G1 cell cycle arrest and induces apoptosis
- Shows improved efficacy compared to Brigatinib
- Significantly inhibits SR cell proliferation with an IC50 of 2 nM
- Down-regulates protein levels of FAK, PYK2, FER, RSK1, and GAK
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