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Medchemexpress LLC Sildenafil | 139755-83-2 | MFCD00951165 | C22H30N6O4S | 500 MG
SDP

Supplier:  Medchemexpress LLC HY15025500MG

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Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM. It is intended for research use only.

  • Potent phosphodiesterase type 5 (PDE5) inhibitor.
  • Exhibits an IC50 of 5.22 nM for PDE5.
  • Potentiates the phosphorylation of ERK1/ERK2 and increases cell proliferation in vitro.
  • Increases intracavernosal pressure (ICP) and ICP/blood pressure (BP) in dog models without significant effects on BP.
  • Decreases the number of TL+-cells and reduces microglia/macrophages in certain in vivo models.
  • Decreases flap necrosis in preclinical animal models by increasing growth factors (FGF and VEGF).
  • Effective in rat cavernous nerve architecture.
  • Available in various quantities and forms, including solid and solution in DMSO.

Catalog No. 50-003-74215


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