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Apexbio Technology LLC Sildenafil mesylate 1308285-21-3 500mg
Supplier: Apexbio Technology LLC B6073500
Sildenafil mesylate (CAS 1308285-21-3) is a potent and selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) exhibiting an IC50 of 3 5 nM By inhibiting PDE5-mediated cGMP hydrolysis it enhances endogenous cGMP levels particularly within corpus cavernosum tissue In vitro sildenafil mesylate reversibly potentiates relaxation responses in precontracted corpus cavernosum strips following sodium nitroprusside exposure or electrical stimulation and increases intracellular cGMP in treated smooth muscle cells In vivo it augments erectile responses in anesthetized canine models This compound is widely used for studying PDE5-related signaling pathways and pharmacological modulation in erectile and vascular function research
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