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Medchemexpress LLC Simufilam hydrochloride | 2480226-07-9 | 99.9% | 295.81 | 50 MG
Supplier: Medchemexpress LLC HY139142B50MG
Simufilam hydrochloride (PTI-125 hydrochloride) is an orally active FLNA modulator. It restores NMDAR signaling and Arc expression, inhibits overactive mTOR signaling, improves insulin sensitivity, and reduces Aβ42-induced neuroinflammation and tau protein hyperphosphorylation, making it suitable for Alzheimer's disease research.
- Restores NMDAR signaling and Arc expression
- Inhibits overactive mTOR signaling
- Improves insulin sensitivity
- Reduces Aβ42-induced neuroinflammation
- Reduces tau protein hyperphosphorylation
- Reduces FLNA-α7nAChR/TLR4 associations
- Restores α7nAChR/NMDAR/IR function
- Enhances spatial/working memory
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