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Medchemexpress LLC Siramesine (hydrochloride) | 224177-60-0 | 99.7% | C30H32ClFN2O | 1 ML
Supplier: Medchemexpress LLC HY14221A10MM/1ML
Siramesine hydrochloride is a potent sigma-2 receptor agonist with subnanomolar affinity (IC50=0.12 nM), showing significant selectivity over sigma-1 receptors. This compound triggers cell death by destabilizing mitochondria and demonstrates anti-cancer activity.
- Potent sigma-2 receptor agonist
- Subnanomolar affinity for sigma-2 receptors
- High selectivity over sigma-1 receptors
- Triggers cell death through mitochondrial destabilization
- Exhibits anti-cancer activity
- Induces cell death in various cell lines
- Activates caspases in HaCaT and U-87MG cells
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