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Medchemexpress LLC SJ3149 CK1α Molecular Glue Degrader | 3026986-17-1 | 99.48% | 376.37 | 1 ML
Supplier: Medchemexpress LLC HY16044410MM/1ML
SJ3149 is a selective and potent molecular glue degrader of CK1α protein with broad antiproliferative activity, intended for use in cancer research. It effectively degrades CK1α protein in MOLM-13 cells at low nanomolar concentrations and inhibits cell growth. In vivo studies also show significant degradation of CK1α protein levels in mice.
- Selective and potent molecular glue degrader of CK1α protein.
- Broad antiproliferative activity against cancer cells.
- Degrades CK1α protein in MOLM-13 cells at 4 nM.
- Inhibits MOLM-13 cell growth with an IC50 of 14 nM.
- Significantly degrades CK1α protein levels in NSG mice at 50 mg/kg.
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