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Apexbio Technology LLC (+)-SK&F 10047 hydrochloride 133005-41-1 10mg
Supplier: Apexbio Technology LLC B658710
( )-SK F 10047 hydrochloride (CAS 133005-41-1) is a well-characterized 1 receptor agonist Studies demonstrate that it enhances hippocampal cholinergic activity in rodents increasing extracellular acetylcholine levels and exhibiting anti-amnesic effects in models of scopolamine-induced memory impairment These actions are reversed by 1 receptor antagonists indicating receptor-specific involvement Additionally in vivo data show that ( )-SK F 10047 mitigates conditioned fear stress when co-administered with anticonvulsants an effect modulated by dopaminergic pathways It is widely used to investigate 1 receptor function in the central nervous system Clinical data are not available
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