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Apexbio Technology LLC Skepinone-L 1221485-83-1 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A38245.1
Skepinone-L (CAS 1221485-83-1) is a selective ATP-competitive inhibitor of p38 mitogen-activated protein kinase (MAPK) This kinase family transduces signals from diverse cellular stressors regulating processes like apoptosis and differentiation Skepinone-L potently inhibits p38 MAPK activity with an IC50 of approximately 5 nM In vitro it dose-dependently reduces phosphorylation of heat shock protein 27 (HSP27) a downstream marker of p38 MAPK in HeLa cells Additionally the compound suppresses key cytokine release (e g TNF- IL-1 IL-10) in human peripheral blood mononuclear cells Oral administration in mice effectively reduced TNF- production illustrating potential applications in inflammation and signaling pathway research
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