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Medchemexpress LLC SMANT hydrochloride | 1177600-74-6 | 99.9% | 375.73 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY10850850MG

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SMANT hydrochloride is a Smoothened (Smo) signaling inhibitor. It acts as an antagonist of Smo accumulation within the primary cilium (PC). This compound demonstrates equivalent activity in inhibiting both the oncogenic form of Smo (SmoM2) and wild-type Smo.

  • For research use only.
  • Inhibits Hh induced Smo accumulation at the primary cilium with an IC50 of 1.1 μM.
  • Blocks the stimulatory action of SAG in Gli-luciferase assay.
  • Inhibits proliferation of cerebellar granule-cell neural progenitors induced by Shh.

Catalog No. 50-003-46088


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