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Medchemexpress LLC SN-011 (STING Inhibitor) | 2249435-90-1 | 99.9% | C25H19FN2O4S | 50 MG
Supplier: Medchemexpress LLC HY14501050MG
SN-011 is a potent and selective mouse and human STING inhibitor, with an IC50 of 76 nM for STING signaling. This compound functions by competing with cyclic dinucleotide (CDN) for the binding pocket of the STING dimer, thereby blocking CDN binding and subsequent STING activation. It is intended for research pertaining to STING-driven autoimmune and inflammatory diseases.
- Potent and selective mouse and human STING inhibitor
- IC50 of 76 nM for STING signaling
- Blocks cyclic dinucleotide (CDN) binding and STING activation
- Useful for research of STING-driven autoimmune and inflammatory diseases
- Inhibits 2′3′-cGAMP-induced Ifnb expression in multiple cell types
- Suppresses STING oligomerization, phosphorylation, and ER-to-Golgi translocation
- Inhibits inflammation and autoimmunity in Trex1-/- mice, improving survival
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