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Apexbio Technology LLC SNS-032 (BMS-387032) 345627-80-7 100mg
Supplier: Apexbio Technology LLC A1980100
SNS-032 (BMS-387032 CAS 345627-80-7) is a selective inhibitor of cyclin-dependent kinases (CDKs) 2 7 and 9 with reported IC50 values of 38 nM 62 nM and 4 nM respectively By targeting CDKs involved in both cell cycle regulation and transcription SNS-032 disrupts phosphorylation of the C-terminal domain (CTD) of RNA polymerase II at Ser2 and Ser5 indicating effective inhibition of CDK9 and CDK7 In cellular models such as chronic lymphocytic leukemia (CLL) SNS-032 reduces CTD phosphorylation in a time- and concentration-dependent manner This compound is valuable in studying CDK-mediated transcriptional and cell cycle processes in cancer research
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