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Apexbio Technology LLC SNS-314 Mesylate 1146618-41-8 50mg
Supplier: Apexbio Technology LLC A412150
SNS-314 Mesylate (CAS 1146618-41-8) is a selective ATP-competitive inhibitor of the mitotic Aurora kinases exhibiting potent inhibition of Aurora A (IC50 9 nM) Aurora B (IC50 31 nM) and Aurora C (IC50 3 nM) Aurora kinases are serine/threonine kinases pivotal in mitosis and are frequently overexpressed in various cancers SNS-314 suppresses tumor cell proliferation in vitro with IC50 values ranging from 1 8 nM to 24 nM across different cell lines and induces cell cycle defects demonstrated by inhibition of histone H3 Ser10 phosphorylation In xenograft models SNS-314 demonstrates significant antitumor activity and sustained Aurora kinase inhibition supporting its utility in cancer research
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