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Medchemexpress LLC SNT-207858 free base | 1104662-66-9 | 99.7% | 616.62 | 1 ML
Supplier: Medchemexpress LLC HY11030A50MG
SNT-207858 free base is a selective, blood-brain barrier penetrating, potent, and orally active melanocortin-4 (MC-4) receptor antagonist. It exhibits high affinity and selectivity for the MC-4 receptor, making it suitable for various research applications.
- Selective MC-4 receptor antagonist.
- Blood-brain barrier penetrating.
- Potent and orally active.
- IC50 for MC-4 receptor (binding): 22 nM.
- IC50 for MC-4 receptor (function): 11 nM.
- 170-fold selectivity versus MC-3.
- 40-fold selectivity versus MC-5.
- Reduces tumor-induced weight loss in C26 adenocarcinoma-induced cachexia models.
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