Apexbio Technology LLC Sobetirome 211110-63-3 50mg

Supplier:  Apexbio Technology LLC A382850

Sobetirome (also termed GC-1 or QRX-431) is a synthetic selective thyromimetic compound targeting thyroid hormone receptors Chemically characterized as 3 5-dimethyl-4-[(4 -hydroxy-3 -isopropylbenzyl)-phenoxy] acetic acid sobetirome functions by modulating lipid metabolism through activation of specific thyroid hormone receptor-mediated pathways In experimental animal models including cholesterol-fed rodents and cynomolgus monkeys sobetirome administration results in dose-dependent reductions in plasma cholesterol Studies in mice indicate it enhances hepatic secretion of cholesterol and promotes bile acid synthesis without inducing LDL receptor mRNA expression Sobetirome also upregulates hepatic HDL receptor scavenger receptor class B type I (SR-BI) It is utilized in research aiming to investigate dyslipidemia mechanisms and explore novel therapeutic approaches targeting thyroid hormone receptor activity

Catalog No. 50-000-64028