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Apexbio Technology LLC Solifenacin succinate 242478-38-2 50mg
Supplier: Apexbio Technology LLC B161450
Solifenacin succinate (CAS 242478-38-2) is a selective muscarinic M3 receptor antagonist derived from tetrahydroisoquinoline and quinuclidine It primarily exerts its effect by competitively blocking acetylcholine binding at M3 receptors thereby attenuating muscarinic-mediated intracellular calcium mobilization In receptor binding assays solifenacin displays highest affinity for human M3 receptors (Ki 12 nM) It also selectively inhibits carbachol-induced contractions in isolated rat bladder tissues Consequently solifenacin succinate is frequently employed in biomedical research focused on lower urinary tract physiology and disorders associated with bladder hyperactivity
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