Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Cayman Chemical Sorafenib Inhibitors
Supplier: Cayman Chemical 1000964425 MG
A multi-kinase inhibitor; inhibits Raf-1 and B-RAF (IC50s = 6 and 22 µM, respectively); inhibits VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit (IC50s = 90, 15, 20, 57, and 58 nM, respectively); selective for these kinases over 12 other kinases (IC50s = >10 µM for all); inhibits proliferation of PLC/PRF/5 and HepG2 cells (IC50s = 6.3 and 4.5 µM, respectively); inhibits tumor growth in a PLC/PRF/5 mouse xenograft model at 30 mg/kg; induces ferroptotic cell death in HT-1080 fibrosarcoma cells at 10 µM but not in a variety of other cancer cell lines; inhibits HCV replication in Huh7.5 cells (IC50 = 7.2 µM)
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?