Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC Sorafenib Tosylate 475207-59-1 20mg
Supplier: Apexbio Technology LLC A824520
Sorafenib tosylate (CAS 475207-59-1) is an orally bioavailable multi-kinase inhibitor that targets Raf serine/threonine kinases and vascular endothelial growth factor receptors (VEGFR) thereby impeding tumor cell proliferation and angiogenesis In vitro it demonstrates an IC50 of 2 09 g/ml in HepG2 hepatocellular carcinoma cells and 0 88 nM in MV4-11 (FLT3-ITD) leukemia cells with dose-dependent antiproliferative and pro-apoptotic effects observed in leukemia cell lines at nanomolar concentrations In vivo administration in a breast cancer bone metastasis model significantly reduces osteolytic lesion volume and soft tissue components compared to controls Sorafenib tosylate is widely employed in oncology research to investigate signal transduction tumor growth and angiogenic pathways
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?