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Medchemexpress LLC Soticlestat | 1429505-03-2 | 99.83% | 373.45 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY109123100MG

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Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, and orally active cholesterol 24-hydroxylase (CH24H) inhibitor with potential for epilepsy syndromes research.

  • It is for research use only, not intended for human use.
  • It inhibits the catalytic activity of human cholesterol 24-hydroxylase (CH24H) in a concentration-dependent manner with an IC50 of 4.5 nM.
  • Treatment with soticlestat lowers brain 24S-hydroxycholesterol in a dose-dependent manner.
  • It substantially reduces premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%.
  • It can suppress potassium-evoked extracellular glutamate elevations in the hippocampus.

Catalog No. 50-003-44346


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