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Medchemexpress LLC Sparfosic acid | 51321-79-0 | 99.3% | 255.12 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY11273210MG

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Sparfosic acid, a DNA antimetabolite agent, is a potent inhibitor of aspartate transcarbamoyl transferase, the enzyme catalyzing the second step of de novo pyrimidine biosynthesis. Sparfosic acid synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines.

  • Causes apoptosis in resistant Br1 cells.
  • Leads to progressive accumulation of cells in S phase and activation of an apoptotic pathway at 300 μM.
  • Increased life-span by 77% to 86% in mice bearing B16 melanoma.
  • Lewis lung carcinoma is highly sensitive to Sparfosic acid.

Catalog No. 50-004-37418


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