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Medchemexpress LLC Sparfosic acid trisodium | 70962-66-2 | 98.0% | 321.06 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY112732B

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Sparfosic acid trisodium is a DNA antimetabolite agent and a potent inhibitor of aspartate transcarbamoyl transferase. It synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines. For research use only.

  • Synergistically enhances the cytotoxicity of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines.
  • Causes apoptosis in resistant Br1 cells.
  • Shows progressive accumulation of cells in S phase and activation of an apoptotic pathway leading to cell death at 300 μM.
  • Increases lifespan by 77% to 86% in mice bearing B16 melanoma (490 mg/kg; i.p.; on days 1, 5, and 9).
  • Highly sensitive to Lewis lung carcinoma, curative in 50% of mice when treated on days 1, 5, and 9 following s.c. implantation.

Catalog No. 50-004-39068


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