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Sigma Aldrich Fine Chemicals Biosciences Sphingomyelin Quantificati
Supplier: Sigma Aldrich Fine Chemicals Biosciences MAK2621KT
Sphingomyelin a sphingolipid consisting of a phospholipid (typically phosphocholine) attached to a ceramide moiety is a major component of cellular membranes. Sphingomyelin is enriched in the exoplasmic leaflet of the cell membrane. Within the cell membrane sphingomyelin interacts with cholesterol to form lipid rafts. The metabolism of sphingomyelin contributes to cellular signaling via the release of ceramide a second messenger that participates in multiple cellular signaling pathways. Sphingomyelin accumulates in Niemann-Pick disease due to deficiencies in sphingomyelinase activity. Increased levels of sphingomyelin is observed in hypercholesterolemia which is characterized by the accumulation of sphingomyelin in arteriosclerotic lesions resulting in ischemic heart disease.
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