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Apexbio Technology LLC Splitomicin 5690-03-9 10mg
Supplier: Apexbio Technology LLC A824210
Splitomicin (CAS 5690-03-9) is a selective inhibitor of Sir2p a NAD -dependent histone deacetylase with an IC50 of 60 M It disrupts the deacetylase activity of Sir2p in vitro as indicated by assays using [ H]-acetylated histone H4 peptides from yeast extracts Splitomicin also inhibits fMLP-induced superoxide anion production in human neutrophils (IC50 40 8 M) associated with elevated cAMP levels and suppressed Mac-1 expression Additionally it attenuates human platelet aggregation induced by multiple agonists in a concentration-dependent manner likely by inhibiting cyclic AMP phosphodiesterase reducing intracellular calcium mobilization and modulating ATP release Splitomicin is a valuable tool for studying sirtuin biology neutrophil activation and platelet function
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