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Medchemexpress LLC SRI-37330 hydrochloride | 2322245-49-6 | 99.7% | C16H20ClF3N4O2S | 100 MG
Supplier: Medchemexpress LLC HY141623100MG
SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. It inhibits glucagon secretion and function, reduces hepatic glucose production, and reverses hepatic steatosis. This compound is used for type 2 diabetes research.
- Inhibits human TXNIP promoter activity in INS-1 cells
- Reduces TXNIP mRNA and protein levels in INS-1 cells
- Inhibits Pol II binding to the E-box motif of the TXNIP promoter
- Lowers glucagon secretion in TC1-6 cells
- Inhibits glucagon-induced glucose output from primary hepatocytes
- Decreases glucagon secretion and blocks hepatic glucose output in mice
- Well tolerated in C57BL/6J mice
- Reverses obesity- and streptozotocin-induced diabetes and hepatic steatosis in mice
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