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Medchemexpress LLC SRI-37330 hydrochloride | 2322245-49-6 | 99.7% | C16H20ClF3N4O2S | 50 MG
Supplier: Medchemexpress LLC HY14162350MG
SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor that reduces glucagon secretion and hepatic glucose production, and reverses hepatic steatosis. It can be used for type 2 diabetes research.
- Inhibits activity of human TXNIP promoter in INS-1 cells
- Lowers mRNA and protein levels of TXNIP
- Inhibits polymerase II (Pol II) binding to E-box motif region
- Lowers glucagon secretion in TC1-6 cells
- Inhibits glucagon-induced glucose output from primary hepatocytes
- Decreases glucagon secretion and action in male C57BL/6J mice
- Blocks hepatic glucose output in male C57BL/6J mice
- Reverses obesity- and Streptozotocin (STZ)-induced diabetes and hepatic steatosis in mice
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