Medchemexpress LLC SSR180711 hydrochloride | 446031-79-4 | 99.90% | 361.66 | 1 ML

Supplier:  Medchemexpress LLC HY1941110MM/1ML

SSR180711 hydrochloride is an orally active, selective, and reversible α7 acetylcholine nicotinic receptor (n-AChRs) partial agonist. It can act on rat α7 n-AChR (Ki=22 nM; IC50=30 nM) and human α7 n-AChR (Ki=14 nM; IC50=18 nM). This compound increases glutamatergic neurotransmission, ACh release, and long-term potentiation (LTP) in the hippocampus.

• Acts on rat α7 n-AChR (Ki=22 nM; IC50=30 nM) and human α7 n-AChR (Ki=14 nM; IC50=18 nM).
• Increases glutamatergic neurotransmission, ACh release, and long-term potentiation (LTP) in the hippocampus.
• Selective for the α7 receptor subtype compared to α4β2, α3β2, α3β4, and α1β1γδ human n-AChR subtypes.
• Rapidly penetrates into the brain (ID50=8 mg/kg; p.o.).
• Dose-dependently inhibits specific [3H]α-BTX binding in the mouse brain.
• Dose-dependently increases extracellular acetylcholine (ACh) levels in the hippocampus and prefrontal cortex of freely moving rats.

Catalog No. 50-003-85075