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Enzo Life Sciences Staurosporine, (1mg), CAS Number: 62996-74-1
SDP

Supplier:  Enzo Life Sciences ALX380014M001

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Apoptosis inducer. Protein kinase inhibitor. Model apoptosis inducer. Potent cell-permeable inhibitor of a variety of protein kinases, e.g. protein kinase C (PKC), CDK1/cyclin B (IC50~5nM), CDK2/cyclin A (IC50=7nM), CDK4/cyclin D (IC50=3-10µM), CDK5/p25 (IC50=4nM), GSK-3β (IC50=15nM), Pim-1 kinase (IC50=10nM).Binds do the ATP binding domain. Did not inhibit PKC-ζ. At 1µM induced apoptosis in CHO cells. Inhibits topoisomerase II directly by blocking transfer of phosphodiester bonds from DNA to active site tyrosine. Alternative Name: Antibiotic AM-2282. Formula: C28H26N4O3. MW: 466.5. CAS Number: 62996-74-1. MI: 14: 8802. Purity: ≥99% (HPLC). Appearance: Off-white to green powder. Solubility: Soluble in ethyl acetate, DMSO (25mg/ml) or dimethyl formamide (25mg/ml); only slightly soluble in chloroform and methanol. Insoluble in water. Use/Stability: Stable for at least 2 years after receipt when stored +4°C. Long Term Storage: +4°C

Catalog No. NC9084391


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