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Reprocell STEMOLECULE DORSOMORPHIN 2MG
Supplier: Reprocell 040024
Stemolecule Dorsomorphin dihydrochloride (also known as Compound C) is a potent inhibitor of AMP-activated protein kinase (AMPK) (Ki=109 nM) and bone morphogenic protein (BMP) signaling. It was identified in a screen for compounds that perturb dorsoventral axis formation in zebrafish3. Dorsomorphin functions through inhibition of BMP type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation. BMP signaling coordinates developmental patterning and have essential physiological roles in mature organisms. Dorsomorphin has been used to probe BMP signaling in iron-hepcidin homeostasis, cardiomyogenesis and osteogenesis.
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