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ABclonal Technology STIM1 Rabbit PolymAb
Supplier: ABclonal Technology A24801PM20UL
This gene encodes a type 1 transmembrane protein that regulates Ca2 influx through store-operated Ca2 channels (SOCs) after intracellular Ca2 depletion Located in the imprinted gene domain of 11p15 5 a tumor-suppressor region alterations in this area are linked to Beckwith-Wiedemann syndrome Wilms tumor rhabdomyosarcoma and cancers of the lung ovarian and breast The gene may also play a role in malignancies disease in this region and early hematopoiesis by mediating attachment to stromal cells Mutations are associated with fatal classic Kaposi sarcoma immunodeficiency from defects in store-operated calcium entry ectodermal dysplasia and tubular aggregate myopathy This gene is near the RRM1 gene with alternative splicing producing multiple transcript variants
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