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STEMCELL Technologies SU11274, Size: 1 mg
Supplier: STEMCELL Technologies 73432
SU11274 is a selective, ATP-competitive inhibitor of MET receptor tyrosine kinase (IC₅₀ = 20 nM; Sattler et al.). It shows good selectivity towards MET versus other receptor tyrosine kinases with IC₅₀ values of 1.3 μM and 9.7 μM for kinase insert domain receptor (KDR) and fibroblast growth factor receptor-1 (FGFR1), respectively (Sattler et al.). It retains activity for certain MET mutants, for example H1112Y and M1268T (Berthou et al.).CANCER RESEARCH· Induces apoptosis and cell cycle arrest in TPR-MET-transformed mouse pre-B (Ba/F3) cells (Sattler et al.).· Inhibits cell viability and motility of human head and neck squamous cell carcinoma cell lines in vitro (Seiwert et al.). · Inhibits cell viability of c-MET-expressing human non-small cell lung carcinoma cell lines in vitro (Ma et al.).
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