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Apexbio Technology LLC SU5416 204005-46-9 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A38475.1

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SU5416 (CAS 204005-46-9) also known as Semaxanib is a small molecule inhibitor designed to block vascular endothelial growth factor receptor (VEGFR2) particularly targeting Flk-1/KDR receptor tyrosine kinase signaling SU5416 effectively inhibits VEGF-induced phosphorylation of Flk-1 thereby interfering with endothelial cell proliferation angiogenesis and subsequent tumor vascularization Preclinical studies demonstrated suppression of tumor growth accompanied by angiogenesis inhibition Additionally SU5416 acts as an agonist of the aryl hydrocarbon receptor (AHR) modulating immune responses via induction of indoleamine 2 3-dioxygenase (IDO) and regulatory T cell differentiation These properties suggest potential utility not only in cancer research but also in investigating autoimmune conditions and transplant tolerance

Catalog No. 50-000-63953


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