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Apexbio Technology LLC SU5614 1055412-47-9 25mg
Supplier: Apexbio Technology LLC B609725
SU5614 (CAS 1055412-47-9) is a small molecule inhibitor targeting protein tyrosine kinases notably FLT3 with an IC50 of 100 nM Tyrosine kinases modulate diverse cellular signaling pathways via phosphorylation events In vitro studies have shown that SU5614 induces growth arrest and apoptosis in c-kit-expressing leukemia cell lines such as Kasumi-1 M-07e and UT-7 by inhibiting SCF-induced tyrosine phosphorylation of c-kit In vivo SU5614 reduces vascular endothelial growth factor (VEGF) levels in bronchoalveolar lavage fluid in murine models implicating its potential in studying VEGF-related pathophysiology such as airway inflammation SU5614 is currently limited to preclinical research applications
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