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![Medchemexpress LLC Sulfur, [4-[[2-(1,1-difluoroethyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amino]phenyl]](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-650.jpg)
Medchemexpress LLC Sulfur, [4-[[2-(1,1-difluoroethyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amino]phenyl] | 1282041-94-4 | 99.9% | 415.33 | 25 MG
Supplier: Medchemexpress LLC 25MGHY100184
DSM265 is a long-duration inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 of 8.9 nM. It can also inhibit the growth of Pf3D7 parasites with an EC50 of 4.3 nM.
- Long-duration inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH).
- Potent in vivo antimalarial activity with 90% effective dose (ED90) of 3 mg/kg per day in NOD-scid IL-2Rγnull (NSG) mice.
- Moderate terminal elimination half-life (t1/2) of 2-4 hours in mice.
- Appears as a solid, white to off-white substance.
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