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Cayman Chemical Sulindac sulfide
Supplier: Cayman Chemical 1000438725 MG
An active metabolite of sulindac; inhibits COX-1 and COX-2 (IC50s = 1.9 and 1.21 µM, respectively); inhibits aldose reductase (IC50 = 279 nM), blocking NADPH-dependent reduction of glucose to sorbitol, and reducing type 2 diabetic complications; inhibits colorectal cancer growth in vitro and in vivo
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