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Medchemexpress LLC SUVN-911 | 2414674-71-6 | 99.13% | 261.15 | 100 MG
Supplier: Medchemexpress LLC HY136146100MG
SUVN-911 is a potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a Ki of 1.5 nM. SUVN-911 has antidepressant activity.
- Potent, selective, brain-penetrant, orally bioavailable α4β2 receptor antagonist (Ki: 1.5 nM).
- Demonstrates antidepressant activity.
- High selectivity for α4β2 over α3β4 nAChR.
- Good selectivity against 70+ receptors (GPCRs, ion channels, enzymes, etc.).
- Devoid of cardiovascular and gastrointestinal side effects.
- Significant antidepressant effects in male Wistar rats (1-10 mg/kg, p.o., daily, 3 days).
- Shows metabolic stability in rats.
- High oral exposure, longer half-life, and adequate brain penetration in Wistar rats (3 mg/kg, p.o.).
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