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Cayman Chemical SynthetIc MaytnsIn 1mg
Supplier: Cayman Chemical 360621 MG
An ansa macrolide with anticancer activity; inhibits the growth of L1210, L-5178-Y, and P388 murine leukemia cells (EC50s = 0.6, 12, and 1.5 nM, respectively); inhibits erythrocyte and brain tubulin polymerization at 20 µM; increases survival in a P388 murine leukemia model from 0.021-0.1 mg/kg; has also been used in the synthesis of cytotoxic payload moieties of ADCs
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